以下文章来源于内分泌早知道 ，作者关注内分泌的 内分泌早知道 . 深度分享内分泌用药经验、病例剖析、指南专业解读并紧跟国内外内分泌领域前沿进展，「每医健」旗下内容平台。 在全球慢性疾病负担日益加重的今天，2型糖尿病已成为威胁人类健康的重大公共卫生问题。最新统计数据显示，全球糖尿病患者总数 已突破4.15亿，其中90%为2型糖尿病，每年导致超过400万人死亡。这种可预防却难以治愈的代谢性疾病，不仅显著增加心血管疾 病、痴呆和癌症的发病风险，更给全球医疗体系带来沉重的经济负担。值得关注的是，发表在《Nutriti on & Di a be t e s》期刊上的突破 性研究为糖尿病预防带来了令人振奋的消息——来自英国生物银行（UK Bi oba nk）历时12年、追踪5 0万人的大规模队列研究首次证 实，日常饮食中增加黄酮类物质的摄入可显著降低2型糖尿病发病风险。 这项具有里程碑意义的研究发现，富含黄酮类化合物的天然食物在糖尿病预防中扮演着关键角色。作为植物性食物中特有的多酚类活性 物质，黄酮类化合物广泛存在于茶叶、苹果、浆果、黑巧克力以及红酒等日常饮食中。研究人员通过长期追踪观察发现，保持较高黄酮 类食物摄入习惯 ...

Core Insights - The article highlights the significant public health threat posed by type 2 diabetes, with over 415 million global patients, 90% of whom have this type, leading to more than 4 million deaths annually [6][7] - A groundbreaking study from the UK Biobank indicates that increasing flavonoid intake through diet can significantly reduce the risk of developing type 2 diabetes [7][9] Group 1: Study Findings - The UK Biobank study tracked over 500,000 individuals for 12 years, confirming that a diet rich in flavonoids is crucial for diabetes prevention [7][10] - Participants with higher flavonoid intake showed a 28% lower risk of developing type 2 diabetes compared to those with lower intake, with specific foods like tea, berries, and apples providing notable protective effects [12][13] Group 2: Research Methodology - The study utilized a novel Flavonoid Diet Score (FDS) to assess the overall dietary patterns related to flavonoid-rich foods and their correlation with diabetes incidence [9][10] - A comprehensive baseline assessment was conducted, collecting multidimensional data on demographics, dietary habits, and lifestyle factors to ensure the reliability of the findings [11] Group 3: Dietary Recommendations - The research suggests that consuming approximately 6 servings of flavonoid-rich foods daily can lead to a significant reduction in diabetes risk, with specific recommendations including 4 cups of tea, 1 serving of berries, and 1 apple [12][13] - The findings support existing dietary guidelines advocating for increased fruit and vegetable consumption as a preventive measure against diabetes [13]

Core Viewpoint - India is proposing to significantly reduce its tariff gap with the US from nearly 13% to below 4% in exchange for exemptions from current and potential tariff increases by the Trump administration, marking a substantial shift in trade policy aimed at lowering trade barriers [1][2] Group 1: Trade Negotiations - The average tariff gap between India and the US will decrease by 9 percentage points, reflecting India's commitment to reducing trade barriers [1] - The total bilateral trade between India and the US is projected to be approximately $129 billion in 2024, with India currently enjoying a trade surplus of $45.7 billion [1] - An Indian official indicated that Japan is next in line for a trade agreement with the US after the UK, highlighting India's strategic approach to trade negotiations [1] Group 2: Market Access and Tariff Reductions - India has offered preferential market access for nearly 90% of goods imported from the US, including a reduction in tariffs [2] - Key export sectors such as gems and jewelry, leather, textiles, and horticultural products are seeking preferential market access to enhance trade conditions compared to other US trading partners [2] - India is also looking to ease export regulations on high-value US goods, including aircraft, luxury cars, and pharmaceuticals, to make the agreement more appealing to Washington [2] Group 3: Technology and Equal Treatment - India is requesting equal treatment in key technology sectors such as AI, telecommunications, biotechnology, pharmaceuticals, and semiconductors, similar to that afforded to US allies like the UK, Australia, and Japan [2]

Core Insights - Anti-inflammatory diets are gaining popularity due to their potential to reduce chronic inflammation linked to various diseases such as obesity, type 2 diabetes, cardiovascular diseases, and cancer [1] Group 1: Anti-inflammatory Foods - Asparagus is rich in polyphenols, which may help prevent cancer, diabetes, and heart disease [3] - Leafy greens like spinach and kale are significant sources of dietary fiber, vitamin E, vitamin C, and other antioxidants [4] - Berries, despite their small size, are nutrient-dense and high in antioxidants, protecting healthy cells from damage [5] - Avocados provide beneficial monounsaturated fatty acids that help prevent chronic inflammation and support gut health [6] - Legumes are high in dietary fiber, which can generate anti-inflammatory short-chain fatty acids [7] - Coffee contains antioxidants that help combat oxidative stress, which is linked to inflammation [8] - Citrus fruits are rich in vitamin C and flavonoids, which have anti-inflammatory properties [9] - Watermelon contains vitamin C, which helps suppress inflammation [10] - Dark chocolate, particularly varieties with over 70% cocoa, can reduce the risk of heart disease and diabetes due to its flavonoid content [11] - Herbs and spices like cinnamon, ginger, and turmeric can reduce inflammation when added to meals [12] - Olive oil is rich in monounsaturated fats and polyphenols, which have anti-inflammatory properties [13] - Fatty fish, such as salmon and mackerel, are high in omega-3 fatty acids that help block inflammation pathways [14] - Pineapple contains bromelain, which can alleviate pain and swelling from injuries [15] - Tea, especially green tea, contains EGCG, an anti-inflammatory compound [16] - Whole grains provide antioxidants and dietary fiber that support gut health [17] - Walnuts contain alpha-linolenic acid, which has anti-inflammatory effects [18] - Fermented foods improve gut microbiome diversity, reducing inflammation [19] Group 2: Pro-inflammatory Foods - It is essential to limit the intake of ultra-processed foods and refined carbohydrates, which can increase inflammation [20] - Fried foods are high in unhealthy fats, contributing to chronic inflammation [21] - Sugary beverages and foods with added sugars are significant contributors to inflammation [21] - Alcohol should be consumed in moderation, with one glass of red wine being sufficient [22] - Excessive consumption of red meat is linked to increased inflammation markers [22]