颜彦介绍，研究还发现，临床治疗后残留的、导致复发的"最小病灶"，也主要源自"高可塑性细胞状 态"细胞群体。而通过动物实验证实，若靶向清除这类细胞，再配合常规化疗或靶向药，几乎能实现肿 瘤的完全清除。(完) 来源：中国新闻网 中新网武汉1月22日电 (马芙蓉 匡敏)中美科研团队联合攻关，找到驱动肺癌进展、造成肿瘤细胞多样性 及产生治疗耐受的关键枢纽。这意味着，未来若能靶向这个控制肿瘤"善变"能力的枢纽，便有望从根本 上抑制肿瘤进化，实现肿瘤彻底根治。 这项由华中农业大学生物医学与健康学院教授颜彦团队，与美国纪念斯隆–凯特琳癌症中心教授图奥马 斯·塔梅拉(Tuomas Tammela)团队合作完成的成果，于北京时间22日发表于国际期刊《自然》(Nature)。 颜彦介绍，恶性肿瘤难治疗、易复发，一个根本原因在于肿瘤细胞能在不同状态间切换以逃避治疗。长 期以来，科学界始终在寻找调控肿瘤"善变"能力的开关，但一直未能得到直接验证。 对此，颜彦团队与合作者开发了一套新型遗传报告系统，该系统能实现对特定肿瘤细胞状态的原位精准 标记、纵向谱系追踪及定点特异性清除，相当于给肿瘤细胞装上"可追踪芯片"和"定点清除开关"，为系 ...

站在AI浪潮中，以"爱你老己"为代表的互联网热梗爆火，年轻人的消费转向正在发生——更热爱具体而真实的世界，更关注附 近的生活体验。一种"热爱当下、重返线下"的快乐生活哲学，作为年度回响，成为人们追寻的焦点。 1月21日，新华网联合美团研究院发布《2025生活服务消费趋势洞察》（以下简称：报告）。2025年，美团APP上与快乐生活相 关的服务消费订单量同比增长36%，95后消费者占比近6成，上海、成都、广州、深圳、北京、杭州、重庆、武汉、郑州、苏州 位列TOP10年轻人玩乐活力之城。据报告，2025生活服务消费九大关键词为：省出快乐、体验平替、乐有所值、追求确定、低 耗社交、内养外练、IP联名、重返附近、玩在当地，提供新奇感、释放压力、彰显态度的"情价比"消费悄然崛起。 省出快乐，花小钱体验当下 用一杯奶茶的钱看一场开放麦，体验一次攀岩或是马术；花9.9元沉浸于古法制香的宁静、感受室内蹦极让肾上腺素飙升，在不 同的主题体验中切换，收获成倍的快乐。报告显示，"周中上班，周末学艺"的9块9主题周生活法成为省钱新潮流。 美团数据显示，2025年"体验课"相关搜索量同比增长70%，10元以下体验课供给量激增近152%。 ...

1月22日，智通财经记者获悉，美团App更新到12.51.202版本，新版本上线"问小团"AI搜索功能，用户 在美团搜索商家、商品时使用此功能，可以获得更准确的本地生活信息服务。 对此美团相关负责人表示，本次App更新升级AI搜索功能，主要是在美团准确及时的本地信息基建基础 上，进一步满足用户的本地生活信息服务需求。"问小团"除搭载美团自研的LongCat模型，还根据不同 用户需求，综合多种主流大模型，能够更好完成不同任务。（智通财经记者 范佳来） ...

Core Insights - The report by Xinhua News and Meituan Research Institute indicates a 36% year-on-year growth in service consumption orders related to a happy lifestyle on the Meituan app by 2025, with nearly 60% of consumers being post-95s [1][4] - The top ten cities for young people's leisure activities include Shanghai, Chengdu, Guangzhou, Shenzhen, Beijing, Hangzhou, Chongqing, Wuhan, Zhengzhou, and Suzhou [1][4] - Nine key trends in service consumption for 2025 are identified: saving happiness, experiential alternatives, value for money, pursuit of certainty, low-cost socializing, internal nurturing and external exercise, IP collaborations, returning to local areas, and playing locally [1][4] Consumption Trends - The search volume for "experience classes" is projected to increase by 70% in 2025, with a 152% surge in the supply of experience classes priced under 10 yuan [3][6] - The search volume for "alternative" products is expected to grow by 26.4%, while the supply of in-store products containing the keyword "alternative" will rise by 97.8% [3][6] - Shared massage chairs at airports and train stations are becoming popular, with the new smart massage space brand "Lemo Bar" achieving over 170,000 orders in a single day [3][6] Healing Services - There is a strong demand for healing services, with a 112% increase in search volume for healing-related keywords and a 111% growth in the number of merchants providing such services [4][6] - Many young consumers view healing services as an "emotional band-aid" [4][6] - Compared to traditional KTVs, self-service KTVs are experiencing significant growth, with a 604% increase in related transactions on Meituan in 2025; orders for unmanned karaoke rooms between 10 PM and 2 AM account for over 40% of total orders, catering to night owls and those with insomnia [4][6]

Core Viewpoint - Meituan has launched an updated version of its app (12.51.202) featuring the "Ask Meituan" AI search function, aimed at enhancing user experience by providing accurate local information for decision-making [1][2][3] Group 1: App Update Features - The new "Ask Meituan" AI search function allows users to quickly obtain accurate decision-making information when searching for merchants and products [1][2] - The app upgrade includes a new banner advertisement slogan, changing from "Your Helper for a Beautiful Life" to "Ask Meituan, All Arranged" [1][2] Group 2: AI Functionality - The AI search function is built on Meituan's robust local information infrastructure, designed to meet users' needs for local life information services [3][5] - "Ask Meituan" utilizes Meituan's self-developed LongCat model and integrates various mainstream large models to better fulfill diverse user tasks [3][5] - The AI can handle both clear commands and vague long sentences, providing users with rapid and accurate information based on merchant addresses, operating hours, store facilities, and extensive user reviews [3][5]

Group 1 - The top three companies by Hong Kong Stock Connect holding ratios are China Telecom (00728) at 70.91%, Green Power Environmental (01330) at 69.45%, and Tianjin Chuangye Environmental (01065) at 67.62% [1][2] - The largest increases in holding amounts over the last five trading days were seen in Alibaba-W (09988) with an increase of 2.229 billion, SMIC (00981) with an increase of 1.693 billion, and Huahong Semiconductor (01347) with an increase of 1.379 billion [1][2] - The largest decreases in holding amounts over the last five trading days were recorded for China Mobile (00941) with a decrease of 2.613 billion, UBTECH (09880) with a decrease of 787 million, and Kuaishou-W (01024) with a decrease of 739 million [1][3] Group 2 - The latest holding ratio rankings for Hong Kong Stock Connect show that China Telecom holds 9.842 billion shares, Green Power Environmental holds 0.281 billion shares, and Tianjin Chuangye Environmental holds 0.230 billion shares [2] - The top ten companies with the largest increases in holdings over the last five trading days include Tencent Holdings (00700) with an increase of 917 million and China Construction Bank (00939) with an increase of 866 million [2] - The top ten companies with the largest decreases in holdings over the last five trading days also include Alibaba Health (00241) with a decrease of 665 million and China Hongqiao (01378) with a decrease of 647 million [3]

Group 1 - The top short-selling stocks include Sun Hung Kai Properties (80016), China Resources Beer (80291), and AIA Group (81299), all with a short-selling ratio of 100.00% [1][2] - The highest short-selling amounts are recorded for Xiaomi Group (01810) at 1.128 billion, Baidu Group (09888) at 1.106 billion, and Alibaba Group (09988) at 995 million [1][2] - The highest deviation values are for Ping An Insurance (82318) at 58.81%, JD Group (89618) at 38.75%, and Sun Hung Kai Properties (80016) at 35.83% [1][2] Group 2 - The top short-selling ratio rankings show Sun Hung Kai Properties (80016) with a short-selling amount of 196,700 and a ratio of 100.00%, followed by China Resources Beer (80291) with 11,500 and 100.00% [2] - The top short-selling amounts list Xiaomi Group (01810) with 1.128 billion, Baidu Group (09888) with 1.106 billion, and Alibaba Group (09988) with 995 million [2] - The top deviation values list Ping An Insurance (82318) with a short-selling amount of 3.2371 million and a ratio of 92.98%, followed by JD Group (89618) with 320,900 and 98.46% [2]

Group 1 - The top three companies with net inflow of southbound funds are SMIC (00981) with 458 million, Sanhua Intelligent Control (02050) with 405 million, and Hua Hong Semiconductor (01347) with 390 million [1] - The top three companies with net outflow of southbound funds are China Mobile (00941) with -601 million, UBTECH (09880) with -516 million, and Sanofi (01530) with -357 million [1] - In terms of net inflow ratio, Haitian Flavoring (03288) leads with 76.61%, followed by Southern Hong Kong Stock Connect (03432) with 62.50%, and CIMC (02039) with 59.57% [1] Group 2 - The top ten companies by net inflow include Tencent Holdings (00700) with 272 million and Alibaba-W (09988) with 263 million [2] - The top ten companies by net outflow include Meituan-W (03690) with -287 million and Bilibili-W (09626) with -242 million [2] - The top three companies with the highest net outflow ratio are Dekang Agriculture (02419) at -50.69%, Sanofi (01530) at -47.05%, and Jianfa International Group (01908) at -45.45% [3]

Market Overview - The Hang Seng Index (HSI) closed at 26,547.45, down by 37.61 points or 0.14% [1] - The index reached a high of 26,639.66 and a low of 26,442.66 during the trading session [1] - The average price for the day was 26,541.16, with a trading volume of 49.443 million shares [1] Blue-Chip Stocks Performance - HSBC Holdings closed at 129.700 HKD, up by 1.17% compared to the previous close [2] - Tencent Holdings closed at 599.924 HKD, down by 0.43% compared to the previous close [2] - Alibaba Group (ADR) saw an increase of 2.19%, closing at 163.200 HKD [3] - Notable declines included NetEase, which fell by 3.70% to 208.000 HKD [3] Individual Stock Movements - Tencent Holdings (ADR) was priced at 599.924, reflecting a decrease of 0.43% compared to its Hong Kong price [3] - Alibaba's ADR was at 164.396, showing an increase of 0.73% compared to its Hong Kong price [3] - HSBC's ADR was at 129.700, indicating an increase of 1.17% compared to its Hong Kong price [3] - Other notable movements included Baidu Group, which increased by 3.29% to 153.700 HKD [3]

Group 1 - Meituan's medical beauty sector is facing aggressive price competition from Alibaba's e-commerce platform, Tmall, which has introduced significant discounts [1][2] - Tmall's "百亿补贴" (100 billion subsidy) strategy has led to the price of the "童颜针" (Aivilan, 84mg) dropping to 1399 yuan per unit, with potential discounts bringing it down to as low as 999 yuan [1][2] - In contrast, Meituan's pricing for the same product remains around 4000 yuan in the Beijing area, indicating a direct challenge to Meituan's market position [2] Group 2 - Meituan has established a strong market presence with nearly 9,500 new medical beauty institutions opened by August 2025, and over 200 upstream brands have joined its platform [3] - Tmall's strategy to attract users through subsidies is a response to the significant barriers Meituan has built with its extensive offline supply network [4] - The medical beauty market has already seen a price war initiated by competitors, such as New Oxygen, which introduced a product priced at 2999 yuan, significantly lower than the market average of 13,000 to 24,000 yuan [5]