Group 1 - The top three companies by Hong Kong Stock Connect holding ratios are China Telecom (00728) at 71.84%, Green Power Environmental (01330) at 69.15%, and China Shenhua (01088) at 68.07% [1] - The latest holding ratio rankings for the top 20 companies show significant ownership levels, with companies like Kaisa New Energy (01108) and COSCO Shipping Energy (01138) also exceeding 67% [1] - The recent five trading days saw Alibaba-W (09988) leading in increased holdings with a rise of 143.50 billion, followed by Yingfu Fund (02800) with an increase of 41.59 billion [1][2] Group 2 - The companies with the largest decreases in holdings over the last five trading days include Meituan-W (03690) with a reduction of 12.14 billion, Great Wall Motors (02333) with a decrease of 8.01 billion, and Xiaomi Group-W (01810) with a drop of 7.57 billion [2] - Other notable companies experiencing significant reductions in holdings include Tencent Holdings (00700) and Li Auto-W (02015), with decreases of 4.65 billion and 4.06 billion respectively [2] - The data reflects a dynamic trading environment, with substantial shifts in investor sentiment towards various companies within the Hong Kong market [2]

Group 1 - Heng Rui Medicine's subsidiary received a notice from the National Medical Products Administration for the marketing application of SHR-A1811, which is suitable for treating locally advanced or metastatic HER2-positive breast cancer patients who have previously received one or more anti-HER2 therapies [1] - The approval process for SHR-A1811 has been prioritized, indicating its potential significance in the breast cancer treatment market, particularly for HER2-positive patients [1] - The unique design of SHR-A1811 and its previous success in lung cancer treatment may provide new options for breast cancer patients and enhance the development of breast cancer therapies [1] Group 2 - Maiwei Biotech signed an exclusive licensing agreement with Kalexo for the 2MW7141 project, which includes potential upfront and milestone payments of up to $1 billion, along with low single-digit royalties [2] - The collaboration is significant as the 2MW7141 project has broad prospects and could fill a market gap, providing new therapies for patients if successful [2] - This partnership is expected to enhance Maiwei Biotech's profitability and international influence, although the high risks associated with biopharmaceutical development and the uncertainty of the $1 billion payment should be noted [2] Group 3 - Kangfang Biotech's AK138D1, a novel antibody-drug conjugate targeting HER3, has received clinical trial approval in China, marking the company's first ADC drug to enter clinical stages [3] - HER3 is a popular target in tumor drug development, with expression or overexpression in various malignancies, including breast, ovarian, lung, colorectal, melanoma, head and neck, cervical, and prostate cancers [3] - The unique design of AK138D1 and its progress in early clinical trials may offer new hope for patients with advanced malignancies and enhance Kangfang Biotech's competitiveness [3] Group 4 - Aikobio has submitted its listing application to the Hong Kong Stock Exchange, with J.P. Morgan and CITIC Securities as joint sponsors, focusing on therapies for respiratory and pediatric diseases [4] - The company has developed a pipeline of six candidate drugs, indicating good progress in its research and development efforts [4] - Although Aikobio has not yet achieved profitability and faces significant R&D costs, a successful listing could provide funding to support commercialization and enhance competitiveness in a competitive market [4]

Group 1 - The Hang Seng Index rose by 1.78% on September 17, with a total southbound trading volume of HKD 178.81 billion, including HKD 94.40 billion net inflow [1] - The southbound trading through Stock Connect (Shenzhen) had a total trading volume of HKD 67.50 billion, with a net inflow of HKD 72.85 billion, while the Shanghai Stock Connect recorded a total trading volume of HKD 111.31 billion and a net inflow of HKD 21.56 billion [1] - Alibaba-W was the most actively traded stock with a total trading volume of HKD 152.17 billion and a net inflow of HKD 50.51 billion, closing up by 5.28% [1][2] Group 2 - Three stocks, including Alibaba-W, Meituan-W, and Baize Medical, have seen continuous net inflows for more than three days, with Alibaba-W leading at a total net inflow of HKD 548.91 billion over 19 days [2] - Xiaomi Group-W recorded the highest net outflow of HKD 6.39 billion, despite its stock price increasing by 2.48% [1][2] - The trading data for September 17 shows that among the active stocks, Meituan-W had a total trading volume of HKD 79.07 billion and a net inflow of HKD 21.00 billion, while Changfei Optical Fiber Cable had a net inflow of HKD 10.21 billion [2]

Group 1 - The Hang Seng Index rose by 1.78% on September 17, closing at 26,908.39 points, with a total net inflow of HKD 9.44 billion through the southbound trading channel [1] - The total trading volume for the southbound trading on September 17 was HKD 178.81 billion, with a net buy of HKD 9.44 billion [1] - The Shanghai Stock Exchange's southbound trading had a total transaction amount of HKD 111.31 billion, with a net buy of HKD 2.16 billion, while the Shenzhen Stock Exchange had a total transaction amount of HKD 67.50 billion, with a net buy of HKD 7.29 billion [1] Group 2 - Alibaba-W was the most actively traded stock on the Shanghai Stock Exchange southbound trading, with a transaction amount of HKD 8.81 billion and a net buy of HKD 2.16 billion, closing up by 5.28% [2] - In the Shenzhen Stock Exchange southbound trading, Alibaba-W also led with a transaction amount of HKD 6.41 billion and a net buy of HKD 2.90 billion, closing up by 5.28% [2] - Other notable stocks included SMIC and Meituan, with transaction amounts of HKD 5.89 billion and HKD 5.19 billion respectively, and both stocks saw positive price movements [2]

Core Insights - On September 17, 2025, Alibaba-W (09988), SMIC (00981), and Meituan-W (03690) were the top three companies by trading volume in the southbound trading of the Stock Connect, with transaction amounts of 88.06 billion, 58.89 billion, and 51.92 billion respectively [1] - Alibaba-W (09988), SMIC (00981), and Meituan-W (03690) also led in the Shenzhen-Hong Kong Stock Connect southbound trading, with transaction amounts of 64.11 billion, 36.49 billion, and 27.15 billion respectively [1] Southbound Trading Highlights - The top three active companies in the southbound trading of the Shanghai-Hong Kong Stock Connect were: - Alibaba-W (09988): 88.06 billion with a net inflow of 21.56 billion - SMIC (00981): 58.89 billion with a net inflow of 1.42 billion - Meituan-W (03690): 51.92 billion with a net inflow of 11.79 billion [2] - Other notable companies included: - Xiaomi Group-W (01810): 32.59 billion with a net outflow of 10.57 billion - Tencent Holdings (00700): 31.36 billion with a net outflow of 3.24 billion [2] Shenzhen-Hong Kong Trading Highlights - The top three active companies in the southbound trading of the Shenzhen-Hong Kong Stock Connect were: - Alibaba-W (09988): 64.11 billion with a net inflow of 28.95 billion - SMIC (00981): 36.49 billion with a net inflow of 2.65 billion - Meituan-W (03690): 27.15 billion with a net inflow of 9.21 billion [2] - Other notable companies included: - Tencent Holdings (00700): 25.39 billion with a net inflow of 3.17 billion - Xiaomi Group-W (01810): 23.75 billion with a net inflow of 4.18 billion [2]

Group 1 - The core point of the article is that Kangfang Biopharma has received Orphan Drug Designation from the FDA for its new generation anti-CD47 humanized IgG4 monoclonal antibody, Lefalimab (AK117), for the treatment of acute myeloid leukemia (AML) [1] Group 2 - The Orphan Drug Designation is significant as it provides certain benefits, including tax credits for clinical trial costs and market exclusivity for seven years upon approval [1] - The designation highlights the potential of Lefalimab in addressing unmet medical needs in the treatment of AML, a condition with limited effective therapies [1] - This development may enhance Kangfang Biopharma's position in the oncology market and attract potential investors interested in innovative cancer therapies [1]

Core Insights - The article highlights the changes in the Hong Kong Stock Connect holdings, with notable increases and decreases in ownership percentages for various companies [1][2]. Group 1: Increased Holdings - Heng Rui Medicine (01276) saw the largest increase in ownership percentage, rising by 1.49% to a total of 13.84% [2]. - Kanglong Chemical (03759) experienced a 1.35% increase, bringing its ownership to 60.51% [2]. - Zhaoyan New Drug (06127) increased by 1.27%, reaching a holding of 43.70% [2]. - Other companies with significant increases include Junshi Biosciences (01877) at +1.24% (59.08%) and China Pacific Insurance (02601) at +1.20% (44.16%) [2]. Group 2: Decreased Holdings - Shandong Molong (00568) had the largest decrease, with a drop of 1.99% to 57.67% [2]. - Yisou Technology (02550) decreased by 0.99%, now holding 37.95% [2]. - Nanjing Panda Electronics (00553) saw a reduction of 0.98%, bringing its ownership to 42.65% [2]. - Other notable decreases include Kailai Ying (06821) at -0.95% (43.35%) and Meizhong Jiahe (02453) at -0.95% (32.06%) [2]. Group 3: Five-Day Changes - In the last five trading days, China Merchants Energy (01138) had the highest increase in ownership, up by 6.19% to 65.63% [3]. - Shandong Molong (00568) also saw a significant increase of 3.74% [3]. - Other companies with notable increases include Zhongchu Innovation (03931) at +3.62% (10.35%) and Youbao Online (02429) at +3.33% (17.38%) [3]. Group 4: Twenty-Day Changes - Over the past twenty days, Anjiren Food (02648) experienced the largest increase, up by 12.29% to 20.54% [4]. - China Merchants Energy (01138) also saw a significant increase of 9.07% [4]. - Other companies with notable increases include Yimai Sunshine (02522) at +7.70% (43.02%) and Lens Technology (06613) at +7.56% (13.64%) [4].

Core Viewpoint - On September 15, the Hang Seng Index rose by 0.22%, closing at 26,446.56 points, with a net inflow of 14.473 billion HKD through the southbound trading channel [1] Group 1: Market Activity - The total trading amount for the southbound trading on September 15 was 156.251 billion HKD, with a net buying amount of 14.473 billion HKD [1] - The Shanghai Stock Exchange's southbound trading accounted for 95.161 billion HKD, with a net buying of 6.968 billion HKD, while the Shenzhen Stock Exchange's southbound trading amounted to 61.089 billion HKD, with a net buying of 7.505 billion HKD [1] Group 2: Active Stocks - Alibaba-W was the most actively traded stock on the Shanghai Stock Exchange southbound trading, with a trading amount of 7.960 billion HKD and a net buying of 2.890 billion HKD, closing with a price increase of 2.32% [2] - In the Shenzhen Stock Exchange southbound trading, Alibaba-W also led with a trading amount of 5.047 billion HKD and a net buying of 2.395 billion HKD, maintaining the same closing price increase of 2.32% [2] - The stock with the highest net selling was Xiaomi Group-W, with a net selling amount of 724 million HKD, while its closing price increased by 1.90% [1][2]

Core Insights - On September 15, 2025, Alibaba-W (09988), Pop Mart (09992), and Yaojie Ankang-B (02617) were the top three stocks by trading volume in the Southbound Stock Connect, with trading amounts of 79.60 billion, 29.45 billion, and 26.94 billion respectively [1] - In the Shenzhen-Hong Kong Stock Connect, Alibaba-W (09988), Xiaomi Group-W (01810), and Tencent Holdings (00700) led the trading volume, with amounts of 50.47 billion, 25.76 billion, and 18.75 billion respectively [1] Southbound Stock Connect - Top Active Companies - Alibaba-W (09988) had a trading amount of 79.60 billion with a net buying amount of +28.90 billion [2] - Pop Mart (09992) recorded a trading amount of 29.45 billion with a net selling amount of -3.25 billion [2] - Yaojie Ankang-B (02617) had a trading amount of 26.94 billion with a net selling amount of -1.39 billion [2] - Other notable companies included Brainstorm Aurora-B (06681) with a trading amount of 26.34 billion and a net buying amount of +2.66 billion [2] - Tencent Holdings (00700) had a trading amount of 23.45 billion with a net selling amount of -2.21 billion [2] Shenzhen-Hong Kong Stock Connect - Top Active Companies - Alibaba-W (09988) led with a trading amount of 50.47 billion and a net buying amount of +23.95 billion [2] - Xiaomi Group-W (01810) had a trading amount of 25.76 billion with a net buying amount of +457.14 million [2] - Tencent Holdings (00700) recorded a trading amount of 18.75 billion with a net buying amount of +26.27 million [2] - Pop Mart (09992) had a trading amount of 18.72 billion with a net selling amount of -1.27 billion [2] - Other significant companies included Meituan-W (03690) with a trading amount of 15.29 billion and a net buying amount of +3.88 billion [2]

Core Insights - The top three companies by Hong Kong Stock Connect holding ratios are China Telecom (00728) at 72.04%, Green Power Environmental (01330) at 69.16%, and China Shenhua (01088) at 67.97% [1] - Alibaba-W (09988), Horizon Robotics-W (09660), and Ping An of China (02318) saw the largest increases in holding amounts over the last five trading days, with increases of +14.898 billion, +1.834 billion, and +1.420 billion respectively [1] - The companies with the largest decreases in holding amounts over the last five trading days include Pop Mart (09992) with a decrease of -2.561 billion, Xiaomi Group-W (01810) with -2.531 billion, and Kangfang Biotech (09926) with -0.911 billion [2] Group 1: Top Holding Ratios - China Telecom (00728) has a holding ratio of 72.04% with 10 billion shares [1] - Green Power Environmental (01330) has a holding ratio of 69.16% with 280 million shares [1] - China Shenhua (01088) has a holding ratio of 67.97% with 2.296 billion shares [1] Group 2: Recent Increases in Holdings - Alibaba-W (09988) increased its holdings by +14.898 billion, adding 98.598 million shares [1] - Horizon Robotics-W (09660) increased its holdings by +1.834 billion, adding 17.948 million shares [1] - Ping An of China (02318) increased its holdings by +1.420 billion, adding 24.8703 million shares [1] Group 3: Recent Decreases in Holdings - Pop Mart (09992) decreased its holdings by -2.561 billion, reducing 9.2515 million shares [2] - Xiaomi Group-W (01810) decreased its holdings by -2.531 billion, reducing 45.9018 million shares [2] - Kangfang Biotech (09926) decreased its holdings by -0.911 billion, reducing 6.7244 million shares [2]