Core Viewpoint - CRISPR technology has made significant advancements in gene editing, but the challenge remains in effectively delivering these tools to the target cells safely and efficiently. A breakthrough from Northwestern University has introduced a new delivery system that enhances the efficiency and accuracy of CRISPR applications in gene therapy [1][3]. Group 1: Current Delivery Methods - Current methods for delivering CRISPR include modified viruses and lipid nanoparticles (LNPs), each with their own limitations. Viruses are efficient but can trigger immune responses, while LNPs are safer but have low delivery efficiency [2]. - Another method involves ex vivo editing, which is complex and costly, making it impractical for most diseases. Thus, there is a need for a safer and more efficient in vivo delivery system [2]. Group 2: New Delivery System - The new system, termed "Lipid Nanoparticle Spherical Nucleic Acids" (LNP-SNA), features a DNA shell that enhances visibility and uptake by cells, significantly improving delivery efficiency [3]. - This innovative delivery vehicle has shown to be over three times more efficient in entering cells compared to traditional lipid nanoparticles, with a significantly lower toxicity profile. The success rate of precise gene editing has increased by over 60% [3]. Group 3: Versatility and Future Applications - The LNP-SNA system is modular, allowing for customization to target specific cell types, such as liver, brain, or cancer cells, thereby enabling precise delivery [4]. - Seven drugs based on similar spherical nucleic acid technology are currently in human clinical trials, with some focusing on cancer treatment. The technology is being promoted by various biotech companies for rapid clinical application [4].

Core Viewpoint - The article discusses the health implications of seasonal changes, particularly the concept of "autumn freezing" and its suitability for different populations, emphasizing the need for tailored health strategies during the fall season [1][2][3]. Group 1: Health Recommendations - "Autumn freezing" is intended for healthy individuals to gradually adapt to cold weather, but it is not suitable for everyone, especially those with hypertension and cardiovascular diseases [1][2]. - For individuals with cardiovascular conditions, temperature fluctuations can increase the risk of serious events like heart attacks and strokes, necessitating protective measures such as staying warm and monitoring blood pressure [2][3]. Group 2: Dietary Guidance - The traditional notion of "autumn fattening" should be redefined; instead of increasing high-fat and high-calorie food intake, the focus should be on nutritional balance, including dietary fiber and quality protein while reducing animal fats [3]. - It is advised to consume foods that alleviate dryness in the fall and to avoid spicy foods, while also maintaining a regular routine and emotional stability during social gatherings [3].

在推进能源装备数字化智能化升级方面，《指导意见》明确，重点突破自主可控工业控制系统、设备智 能感知和智能运维、网络设施、作业机器人等数智产品，通过构建"感知—规划—决策—执行"闭环体 系，推动覆盖开采、转换、存储、输送全过程的能源装备数字化智能化升级。 上述相关负责同志谈道，为推动重点任务的落实，《指导意见》从强化企业主体地位、加强产业平台建 设、加强全面质量管理、鼓励首台（套）应用、建立完善高层次标准体系、深化国际开放合作、加大政 策支持力度等7个方面，提出了优化产业创新生态环境的措施。 （文章来源：科技日报） 《指导意见》提出，到2030年，我国能源关键装备产业链供应链实现自主可控，高端化、智能化、绿色 化发展取得显著成效，技术和产业体系全球领先，国际影响力持续提升，有效保障高效智能能源勘探开 发、低碳高效能量转换、低成本高可靠能源存储、高效稳定能源输送等战略任务，有力支撑新型能源体 系建设。 "能源装备是构建新型能源体系的重要载体。"国家能源局科技司相关负责同志表示，推进能源装备高质 量发展，是全面贯彻"四个革命、一个合作"能源安全新战略和创新驱动发展战略，支撑实现"碳达峰、 碳中和"目标，加快推进制造 ...

Core Insights - The global demand for computing power driven by artificial intelligence (AI) is creating unprecedented challenges for data center infrastructure, necessitating the development of next-generation AIDC (AI Data Center) facilities [1][2] - The first "AIDC Industry Development Conference" was held in Shanghai, focusing on the theme "Releasing Powerful Computing Power, Opening a New Era of AIDC," and a pre-release of the "AIDC Infrastructure Standards" was announced to guide future development [1] Group 1: AIDC Infrastructure Challenges - The rapid increase in computing power density and power load in AI data centers is leading to significant challenges related to heat, electricity, and space [2][3] - Liquid cooling data centers are becoming a necessary choice for AIDC due to their ability to handle higher power loads and complex cooling requirements compared to traditional air-cooled systems [2][3] Group 2: Advantages of Liquid Cooling - Liquid cooling technology can improve energy utilization efficiency by at least 25% and space utilization by 4-8 times compared to air cooling systems [3] - The shift to liquid cooling is essential as AI data centers may operate thousands to tens of thousands of processors, which traditional air cooling cannot efficiently manage [3] Group 3: Need for Standardization - Current AIDC infrastructure standards are not well-established, leading to challenges in planning, delivery, and operation, which could hinder the sustainable development of the industry [4] - There is a pressing need for a comprehensive AIDC standard that addresses structural, electrical, and cooling requirements to promote healthy industry growth [4][6] Group 4: Future AIDC Development - AIDC construction should transition from "component stacking" to "vertical collaboration and optimization," focusing on high-density power supply, cooling, green energy, and rapid deployment [5] - The "AIDC Room Reference Design White Paper" was released, providing practical guidelines for the industry, emphasizing the need for flexible cooling solutions and adequate building design to accommodate heavier AI servers [6][7] Group 5: Collaborative Ecosystem - Building an open, shared, and standardized ecosystem is crucial for the sustainable development of AI computing infrastructure [7] - The industry is encouraged to accelerate the establishment of standard systems and promote collaboration across the supply chain to overcome key technical challenges related to heat, electricity, and space [7]

自通过初评项目公示之日起15日内，任何单位或者个人对公示项目持有异议的，应当按照《国家科 学技术奖励条例实施细则》《国家科学技术奖异议处理办法》等有关规定，以书面方式提出，并提供必 要的证据材料。个人提出的，须写明姓名、联系电话等，并亲笔签名；单位名义提出的，须写明联系 人、联系电话等，由单位法定代表人签字并加盖公章。我办按有关规定对异议提出者相关信息予以保 护。 9月22日，科技部官网发布《国家科学技术奖励工作办公室公告第103号》。 公告称，2025年度国家科学技术奖初评工作已经结束。现将通过初评的60项国家自然科学奖项目、 51项国家技术发明奖通用项目、134项国家科学技术进步奖通用项目，在国家科技管理信息系统公共服 务平台（https://service.most.gov.cn/jl）公示。通过初评的20项国家技术发明奖专用项目和37项国家科学 技术进步奖专用项目在委托管理单位、提名单位及项目完成单位等进行内部公示。 ...

Group 1 - The core viewpoint of the report indicates that the technology transfer activities in China are becoming increasingly active, with a total contract amount of 226.91 billion yuan in 2024, representing a growth of approximately 10% compared to the previous year [1] - In 2024, 4,059 universities and research institutions engaged in technology transfer through various methods, resulting in a total of 661,000 contracts, showing an overall upward trend in both contract amounts and numbers [1] - The number of institutions with technology transfer contracts exceeding 100 million yuan reached 415, marking a year-on-year increase of 4.1% [1] Group 2 - By the end of 2024, there were 18,248 dedicated personnel involved in technology transfer across universities and research institutions, with an increasing number establishing technology transfer agencies or collaborating with market-oriented transfer institutions [1] - A total of 1,084 universities and research institutions established technology transfer agencies tailored to their characteristics, accounting for 26.7% of the total reported [1] - 2,209 universities and research institutions formed dedicated teams for technology transfer, representing 54.5% of the total reported [1] Group 3 - The collaboration between universities and enterprises in research and development has deepened, with 1,329 universities and research institutions co-establishing research and transfer institutions and service platforms, which is 32.7% of the total reported [2] - The number of co-established institutions and platforms reached 19,772, which play a significant role in facilitating the effective matching of supply and demand for technology transfer [2] - The report highlights ongoing reforms in institutional mechanisms, talent systems, and high-value result cultivation, contributing to the industrialization of major technological innovations in strategic emerging fields [2] Group 4 - The "Technical Manager MOOC" course was launched, providing comprehensive online resources for technology managers, covering key aspects of the technology transfer process [3] - The course utilizes innovative formats such as animation and case simulations to enhance the theoretical and knowledge levels of technology managers [3]

Core Viewpoint - The "Nickel City Innovation Week" in Jinchang City, Gansu Province, highlights the integration of technology and economy, showcasing innovative achievements and fostering collaboration among government, enterprises, academia, and research institutions [1] Group 1: Innovation and Industry Development - Jinchang City has focused on enhancing technological innovation, resulting in a perfect score in two innovation indicators during the Gansu Province business environment assessment in the first half of 2025, ranking first in the province [1] - The production of "hand-teared nickel," a super-thin material used in the core of new energy batteries, demonstrates the city's advancements in the new energy battery industry, with local supply rates for raw materials reaching 77% [2] - Jinchang has established a comprehensive industrial system for new energy batteries, focusing on nickel-cobalt-manganese lithium batteries and lithium iron phosphate batteries [2] Group 2: Support for Enterprises - The city has implemented various support policies, including the establishment of industrial investment funds and risk compensation funds, to empower enterprises in their innovation efforts [2] - Over 95% of major provincial and municipal scientific projects are led by enterprises, indicating strong collaboration between industry and academia [3] - The total number of high-tech enterprises in Jinchang has reached 87, with 61 recognized as provincial-level innovative enterprises [3] Group 3: Collaborative Platforms - The establishment of the Gansu Yuansheng New Dairy Sheep Industry Research Institute exemplifies the collaboration between universities and enterprises to enhance technological innovation [4] - Multiple collaborative bases have been created, including industrial internet security laboratories and joint training bases, to support industry development [4] - Significant technological breakthroughs have been achieved, such as the development of nickel-based high-temperature alloys and domestication of medical heavy ion accelerator materials [5] Group 4: Future Directions - Jinchang City aims to continue implementing innovation-driven development strategies, optimizing the innovation ecosystem, and enhancing innovation capabilities to promote the deep integration of technological and industrial innovation [5]

●创新文化是一系列有利于新的知识特别是新的科学技术知识生产、传播和应用，鼓励人们 包容、支持和参与创新的信念、价值观和思维习惯。 ●创新不再是实验室里的线性过程，而是在全民讨论和跨界碰撞中涌现。这正是中国式创新 文化充满活力的底色。 ●科研是一项全球事业，但每个国家又面临着其特定生态系统内的独特挑战和优先事项。在 技术和创新方面，必须因地制宜提供科研相关服务，最终形成独特、包容的创新文化。 东海之滨创新潮涌，黄浦江畔思想激荡。9月20日至22日，2025浦江创新论坛在上海举行。在众多主题 论坛中，创新文化论坛以其独特的视角和深远的意义，成为本届论坛最受瞩目的亮点之一。 21日下午，由科技日报社、中国科学技术发展战略研究院、上海市科学学研究所承办的创新文化论坛在 上海东郊宾馆举办。论坛聚焦"变革时代的创新文化"主题，邀请来自全球的专家学者从多元视角分享对 创新文化的深刻洞察。嘉宾们一致认为，中国波澜壮阔、久久为功的创新文化，是一种鼓励创新、宽容 失败、开放协同、跨界融合的文化，为中国乃至全球的科技创新提供着不竭的精神动力，指引人类文明 穿越变革之路，驶向更加广阔的星辰大海。 推动科技与文化双向奔赴 当前，我国正 ...

统筹科技资源、深化跨区协同、推动科创产创融合、强化科创中心引领，四大方向助力区域科技创新再 升级！（记者刘蓉蓉 赵卫华） ...

Core Viewpoint - The production of computers, laptops, and mobile phones is expected to become fully intelligent within approximately five years, significantly impacting China's manufacturing industry [1] Group 1 - Current manufacturing in China is primarily semi-manual and semi-automated, requiring production line changes for new mobile phone models [1] - The concept of a "universal production line" driven by knowledge and end-to-end learning could revolutionize the manufacturing process in China [1]