Core Viewpoint - The A-share market opened lower due to statements related to Trump's tariffs, but this does not change the long-term slow bull trend of the market. Long-term, dividend and technology assets are expected to yield excess returns, with a barbell strategy gaining attention [1]. Group 1: Market Performance - As of October 13, 2025, the Shanghai 180 Index (000010) fell by 1.04%. Among its constituent stocks, Kingsoft Office (688111) led with a rise of 17.18%, while Jiangxi Copper (600362) fell by 5.44% [1]. - The Shanghai 180 ETF Index Fund (530280) decreased by 0.98%, with a latest price of 1.21 yuan. Over the past two weeks, the fund has accumulated a rise of 1.91% [1]. Group 2: Index Composition - The Shanghai 180 Index closely tracks the performance of 180 large-cap, liquid securities from the Shanghai stock market, reflecting the overall performance of core listed companies [2]. - As of September 30, 2025, the top ten weighted stocks in the Shanghai 180 Index include Kweichow Moutai (600519), Zijin Mining (601899), and others, accounting for a total of 26.75% of the index [2]. Group 3: Stock Performance - The performance of key stocks within the index shows varied results, with Kweichow Moutai down by 0.61% and Zhongjin International (688981) up by 2.92% [4].

Core Insights - On October 10, a total of 3,717 stocks in the A-share market received financing funds, with 560 stocks having a buying amount exceeding 100 million [1] - The top three stocks by financing buying amount were ZTE Corporation, Dongfang Wealth, and Newyeason, with amounts of 4.643 billion, 3.104 billion, and 2.867 billion respectively [1] - Two stocks had financing buying amounts accounting for over 30% of the total transaction amount, with Fengshen Co., Yuandong Bio, and Hongrun Construction leading at 35.77%, 31.62%, and 30.0% respectively [1] - A total of 45 stocks had a net financing buying amount exceeding 100 million, with Dongfang Wealth, ZTE Corporation, and WuXi AppTec ranking first, second, and third at 701 million, 623 million, and 586 million respectively [1] - The formation of a MACD golden cross signal indicates a positive trend for certain stocks [1]

Summary of Wuxi Apptec Conference Call Company Overview - **Company**: Wuxi Apptec - **Industry**: Pharmaceutical Services - **Market Position**: Largest pharmaceutical R&D services platform in Asia by total revenue [38][39] Key Takeaways Resilient Performance and Customer Retention - Wuxi Apptec is on track to meet its full-year guidance despite macroeconomic uncertainties and industry challenges, demonstrating the resilience of its Contract Research, Development, and Manufacturing Organization (CRDMO) model [3] - Customer retention is exceptionally high, with over 99% of clients continuing from discovery through to manufacturing, providing strong revenue visibility [3][6] Strategic Capacity Expansion - The company is expanding its capacity for small molecules and peptides, particularly for GLP-1 assets, with plans to increase SPS capacity from 48,000 liters to 100,000 liters by year-end [4][30] - Wuxi maintains a molecule-agnostic approach, focusing on infrastructure readiness and flexibility to meet diverse customer needs [4] Margin Improvement and Geographic Diversification - Margin improvements are anticipated through a richer late-stage project mix and yield optimization, supported by disciplined capital allocation [5] - The company is exploring capacity expansion in Switzerland and Singapore to mitigate geopolitical and tariff risks, despite higher operational costs (up to 3 times compared to China) [5][35] Market Dynamics and Pipeline Positioning - The pipeline is aligned with market trends, but early-stage projects have faced funding constraints, particularly in the U.S. [6] - Pricing pressures in China persist, and demand outside China has not fully recovered [6] Financial Projections - Revenue projections for FY 2024A to FY 2027E are as follows: - FY 2024A: 39,241.4 million - FY 2025E: 44,471.6 million - FY 2026E: 52,182.5 million - FY 2027E: 60,282.0 million - EBITDA and net profit are also projected to grow significantly during this period [7] Investment Thesis - Wuxi Apptec is rated as a "Buy" due to: - Over 33% growth in non-COVID backlog - Strong growth in TIDES business (approximately 60% growth expected in 2025) driven by robust demand for peptides [10][20] Risks and Catalysts - Risks include potential decreases in demand, competition, and project failures [40][41] - Catalysts for growth include new CRO/CMO contracts, strong GLP-1 backlog growth, and advancements in clinical pipelines [28] Sustainability Initiatives - The company has set targets for reducing carbon emissions, energy consumption, and water usage by 2030 compared to a 2020 baseline [29] Conclusion Wuxi Apptec is well-positioned to capitalize on growth opportunities in the pharmaceutical services industry, supported by strong customer retention, strategic capacity expansions, and a robust pipeline. However, it must navigate ongoing market challenges and geopolitical risks to maintain its competitive edge.

Core Viewpoint - The A-share and Hong Kong stock markets experienced significant fluctuations, with the A-share medical sector facing downward pressure, particularly in the CXO segment, while the innovative drug sector remains a focal point for investors despite recent adjustments [1][5][7]. Group 1: A-share Market Performance - The A-share medical sector opened lower and continued to decline, with major player WuXi AppTec leading the drop at 7.2%, and the largest medical ETF (512170) falling by 2.03% [1]. - The overall trend for the medical sector has been a recent upward movement, indicating potential for rebound despite short-term corrections [1]. Group 2: Hong Kong Market Performance - The Hong Kong medical sector initially showed signs of recovery but faced renewed selling pressure, with innovative drug stocks like Rongchang Bio and Innovent Biologics dropping over 11% [1][5]. - The Hong Kong innovative drug ETF (520880) experienced a decline of 2.25%, losing all moving averages, with a trading volume of 3.69 billion [1][5]. Group 3: Innovative Drug Sector Insights - The innovative drug sector, despite entering a phase of adjustment since September, continues to attract significant investor interest, with the Hong Kong innovative drug ETF (520880) raising over 675 million in the last 20 days [5][7]. - Analysts suggest that the innovative drug sector may see renewed opportunities in Q4, driven by upcoming academic conferences and policy implementations that could support domestic innovation [7]. Group 4: Investment Strategies - Investment strategies in the medical sector are focusing on two main lines: identifying companies with strong Q3 performance and exploring opportunities in innovative drugs for potential rebounds [7]. - The fund manager of the Hong Kong innovative drug ETF (520880) emphasizes the importance of balancing investments within the sector, including medical devices and services that may gain market attention [7].

Investment Rating - The report maintains an "Overweight" rating for the pharmaceutical and biotechnology sector [1] Core Viewpoints - The impact of the tariff war on the pharmaceutical sector is limited, with a positive outlook on innovation and domestic substitution [1][16] - The ranking of favored sub-industries is: innovative drugs > research services > CXO > traditional Chinese medicine > medical devices > pharmacies [2][10] - Specific stock recommendations include Zhaoli Pharmaceutical, Fangsheng Pharmaceutical, and Dong'e Ejiao from the traditional Chinese medicine sector, and Yuyue Medical and United Imaging Healthcare from the medical device sector [2][11] Summary by Sections Industry Trends - The A-share pharmaceutical index has seen a year-to-date increase of 21.87%, while the Hang Seng Biotechnology Index has increased by 94.11% [5][10] - Recent stock performance highlights include Zhend Medical (+21.00%) and Wanbangde (+12.01%) in A-shares, while Hong Kong stocks like Kaisa Health (+48.84%) have also performed well [5][10] Tariff Policy Analysis - The U.S. tariff policy on pharmaceuticals is expected to have minimal impact on China's pharmaceutical industry, as most exports consist of raw materials [16][22] - The tariff primarily affects brand-name and patented drugs, while generic drugs and raw materials are largely exempt [16][19] R&D Progress and Company Dynamics - Significant advancements in innovative drug development include the initiation of Phase III clinical trials for the first selective CDK2 inhibitor and breakthroughs in ADC treatments for triple-negative breast cancer [5][10] - The report emphasizes the importance of research quality and efficiency in CRO services, which remain unaffected by tariff policies [16][22] Market Performance Review - The pharmaceutical index's P/E ratio stands at 39.05, slightly above historical averages, indicating a robust market outlook despite recent fluctuations [5][10] - The report notes that the recent stock price declines in the innovative drug sector are primarily driven by market sentiment rather than fundamental changes [22]

行 业 及 产 业 医药生物 2025 年 10 月 12 日 本 周 申 万 医 药 生 物 指 数 下 跌 行 业 研 究 / 行 业 点 评 本期投资提示： ⚫ 市场表现：本周申万医药生物指数下跌 1.2%，同期上证指数上涨 0.4%，万得全 A（除 金融石油石化）下跌 0.5%。本周医药生物指数在 31 个申万一级子行业中表现排名第 25 。 各 三 级 板 块 涨 跌 幅 为 ： 原 料 药 （ -0.7% ） 、 化 学 制 剂 （ -2.5% ） 、 中 药 （+1.5%）、血液制品（+1.4%）、疫苗（+0.7%）、其他生物制品（-1.7%）、医疗 设备（-0.2%）、医疗耗材（+0.2%）、体外诊断（-0.6%）、医药流通（+0.8%）、 线下药店（+0.3%）、医疗研发外包（-5.3%）、医院（+1.8%）。当前医药板块整体 估值 30.9 倍，在 31 个申万一级行业(2021)中排名第 10。 本研究报告仅通过邮件提供给 中庚基金 使用。1 《本周医药上涨 3.1%，医保局发布按病种 付费管理暂行办法和医保"双目录"初审 名单，司美在美获批治疗 MASH ——医药 行业周报（2025/ ...

Investment Rating - The industry rating is maintained as "Buy" [6][10]. Core Views - The recent geopolitical tensions between China and the US have led to a pullback in the medical services sector, but the long-term positive trend remains unchanged due to the strengthening of domestic companies' capabilities in the innovative drug industry [10][64]. - The report emphasizes the importance of company capabilities in driving industry development, suggesting a focus on high-growth areas such as ADC CDMO and peptide CDMO, as well as companies like WuXi AppTec and Haoyuan Pharmaceutical [10][64]. Summary by Sections Industry Performance - The pharmaceutical and biological sector fell by 1.20%, ranking 25th among 31 primary industries [2][12]. - The medical services sub-sector reported a decline of 3.37%, closing at 7156.07 points, which is a significant drop compared to other sub-sectors [24][25]. Company Performance - Notable performers in the medical services sector include Sanbo Brain Science (+3.5%), Meinian Health (+2.8%), and Aier Eye Hospital (+2.6%), while underperformers include Medicy (-8.8%) and Kanglong Chemical (-7.5%) [3][31]. - The report highlights a significant pullback in CXO-related companies [3][31]. Valuation Metrics - The current PE ratio for the medical services sector is 36.92X, with a PB ratio of 3.77X, showing a decrease from the previous week [4][32]. - The PE ratio has fluctuated between a maximum of 41.13X and a minimum of 28.46X over the past year [4][32]. Investment Recommendations - The report suggests focusing on high-growth companies in the medical outsourcing services and those with expected improvements in profitability, particularly in third-party testing laboratories and consumer healthcare sectors like ophthalmology and dentistry [10][64].

Group 1 - A total of 61 stocks received ratings from brokers between October 5 and October 11, with 36 stocks receiving a "buy" rating [1] - The stocks with the highest expected price increases based on the latest closing prices are Kema Technology (301611.SZ) at 23.14%, WuXi AppTec (603259.SH) at 15.45%, and Silis (601127.SH) at 15.18% [1] - The stocks that received attention from multiple brokers include Goldwind Technology (002202.SZ), Silis (601127.SH), and WuXi AppTec (603259.SH) [1] Group 2 - The industries with the highest number of stocks receiving broker attention are light industry manufacturing, textile and apparel, and automotive [2]

Core Viewpoint - WuXi AppTec (603259.SH) has completed a block trade selling shares of its associate WuXi AppTec (2268.HK) for approximately HKD 2.346 billion, marking the fourth sale of its shares this year, which has contributed a total of RMB 4.351 billion to the company's net profit [1][2]. Group 1 - On October 8, WuXi AppTec sold 30.3 million shares of WuXi AppTec, representing 2.47% of the latter's total share capital [2]. - The net investment gain from this sale is expected to impact the company's after-tax net profit for the fiscal year 2025 by approximately RMB 1.679 billion, accounting for over 10% of the latest audited net profit attributable to shareholders for the fiscal year 2024 [2]. - This divestment aligns with a previously authorized strategy from a shareholder meeting on September 23, allowing the investment department to dispose of listed domestic and foreign stocks when market conditions are favorable, with a total limit of 15% of net assets attributable to shareholders [2][3]. Group 2 - WuXi AppTec has strategically timed its stock sales, having previously sold a total of 137 million shares of WuXi AppTec this year, generating approximately HKD 4.604 billion, bringing the total cash realized to nearly HKD 7 billion, significantly boosting the company's profit performance [2]. - The proceeds from this sale will be reinvested into global capacity expansion and capability building, enhancing its integrated CRDMO business model, and attracting top-tier research talent to support long-term growth [3]. - As of October 10, WuXi AppTec's stock closed at RMB 104.72 per share, reflecting a year-to-date increase of 95.02%, while WuXi AppTec's stock closed at HKD 71.85 per share, with a year-to-date increase of 134.42% [3].

Core Viewpoint - The report outlines the changes in shareholding and voting rights of WuXi AppTec Co., Ltd. due to the expiration of the concerted action agreement among certain shareholders, which does not affect the actual control of the company [46][48][49]. Group 1: Shareholding Changes - As of the report signing date, the total shareholding of the information disclosure obligors was 598,454,017 shares, accounting for 20.16% of the total share capital [52]. - Following the termination of the concerted action agreement, the combined voting rights of the information disclosure obligors decreased from 20.01% to 18.46% due to the exclusion of 1.55% held by the original concerted action parties [23][53]. - The total share capital of the company changed from 2,968,549,263 shares to 2,965,692,554 shares during the reporting period, affecting the shareholding percentages [54][58]. Group 2: Concerted Action Agreement - The original concerted action agreement was signed on March 23, 2016, and was terminated on October 9, 2025, allowing the parties to act independently [48][49]. - The original concerted action parties have committed to not reducing their shareholdings in WuXi AppTec for six months following the announcement of the termination [46][50]. - The termination of the concerted action agreement simplifies the shareholder voting mechanism and enhances decision-making efficiency [49][51]. Group 3: Future Plans - As of the report signing date, there are no explicit plans for the information disclosure obligors to increase or decrease their shareholdings in WuXi AppTec within the next 12 months [20].