Investment Rating - The report maintains a "Positive" investment rating for the industry [2]. Core Insights - NLRP3 inflammasome is identified as a significant target for drug development due to its role as a "receiver and converter" of inflammatory signals, indicating substantial therapeutic potential [11][12]. - NLRP3 inhibitors, particularly VTX3232, have shown remarkable anti-inflammatory effects and preliminary validation for reducing cardiovascular (CV) risks [22][28]. - The market potential for targeting NLRP3 is significant, with a potential patient population of approximately 25 million in the cardiovascular anti-inflammatory drug scenario [39]. Summary by Sections 1. NLRP3 Inflammasome: A Major Drug Target - NLRP3 acts as an intracellular sensor detecting various microbial patterns and endogenous danger signals, leading to the assembly and activation of the NLRP3 inflammasome [11]. - The NLRP3 inflammasome is linked to several common diseases, including obesity, diabetes, and cardiovascular diseases, highlighting the market potential for NLRP3-targeted therapies [12]. 2. Efficacy of NLRP3 Inhibitors - VTX3232 demonstrated a rapid and significant reduction in high-sensitivity C-reactive protein (hsCRP) levels, with an 80% reduction within the first week and a sustained effect over 12 weeks [28]. - The safety profile of VTX3232 is comparable to placebo, with adverse events occurring at similar rates across treatment groups [29]. 3. Identifying Next-Generation NLRP3 Inhibitors - BGE-102, a novel NLRP3 inhibitor, has shown promising early-phase data, indicating its potential to lower hsCRP levels significantly in obese participants [65][67]. - The competitive landscape for NLRP3 inhibitors includes several active candidates, with BGE-102 being highlighted for its unique structure and mechanism [54].

NLRP3："抗炎"能力初步验证，心血管 领域又一潜在重磅靶点 ——美股生物科技前瞻系列 长江证券研究所医药研究小组 2026-02-25 %% %% %% %% research.95579.com 1 分析师及联系人 证券研究报告 • 证券研究报告 • 评级 看好 维持 分析师 彭英骐 分析师 刘长洪 SAC执业证书编号：S0490524030005 SAC执业证书编号：S0490525070007 SFC执业证书编号：BUZ392 %% %% %% %% research.95579.com 2 目 录 01 NLRP3炎症小体：炎症信号的"接收转化 器"，成药潜力巨大 02 NLRP3抑制剂抗炎效果突出，用于降低CV 风险初步验证 03 寻找下一个优质NLRP3抑制剂 04 风险提示 %% research.95579.com 3 01 NLRP3炎症小体：炎症信号的"接收转化器"， 成药潜力巨大 %% %% %% %% research.95579.com 4 NLRP3炎症小体是人体炎症信号的"接收转化器" %% %% %% %% research.95579.com 5 ➢ NLRP3是一种细胞 ...

Investment Rating - The industry investment rating is "Positive" and maintained [9] Core Viewpoints - The report emphasizes the strengthening expectation of price increases for electronic fabrics, driven by explosive demand and capacity constraints, indicating a "super cycle" characterized by strong demand rigidity and prolonged duration [5][6] - The report identifies three main lines for 2026: the stock chain, the Africa chain, and the AI chain, suggesting strategic focus areas for investment [8] Summary by Relevant Sections Basic Situation - Cement shipments are experiencing seasonal declines, with an average shipment rate of approximately 9% in key regions, a month-on-month decrease of about 15 percentage points, and a year-on-year decrease of about 4 percentage points [7][22] - Glass inventory has slightly increased, with a total inventory of 51.63 million weight boxes, a month-on-month increase of 2.14 million weight boxes, reflecting a 4.32% growth [7][30] Outlook for 2026 - The stock chain focuses on optimizing demand and clearing supply varieties, with residential renovation demand expected to rise from 50% currently to nearly 70% by 2030 [8] - The Africa chain highlights undervalued growth opportunities in the African market, recommending leading companies such as Keda Manufacturing and Huaxin Cement [8] - The AI chain looks at the industrial upgrade of special electronic fabrics, with a focus on Low-Dk products and domestic substitution opportunities [8] Price and Inventory - The national average price for cement before the festival was 346.29 yuan/ton, with a month-on-month decrease of 0.32 yuan/ton and a year-on-year decrease of 47.90 yuan/ton [23] - The national average price for glass before the festival was 63.24 yuan/weight box, with a month-on-month increase of 0.06 yuan/weight box and a year-on-year decrease of 11.07 yuan/weight box [32]

[Table_Summary] 我们认为，从练内功到带农户，从富农户到兴产业，德康农牧在生猪养殖行业探索了一条真正 实现联农带农和富农强农的产业振兴之路。深耕育种打牢养殖根基，成功构建起高壁垒的自主 繁育体系；二号农场重构养殖环节的生产关系，最大程度激发农户养殖的潜力和动能；"百村百 万"工程带动二号农场模式的快速落地，更好地赋能乡村振兴从而实现强农富农。在生猪养殖 行业进入高质量发展新时代，德康农牧以"不难不做"的企业基因，将行业难题系统性地转化 为自身强大的护城河，最终形成"低投入、高周转、高回报"的生猪养殖体系，持续重点推荐。 分析师及联系人 [Table_Author] 顾熀乾 陈佳 SAC：S0490519060003 SAC：S0490513080003 SFC：BQT624 [Table_scodeMsg1] 港股研究丨公司深度丨德康农牧（02419.HK） [Table_Title] 德康农牧深度系列二：联农标杆，富农典范 %% %% %% %% research.95579.com 1 丨证券研究报告丨 报告要点 请阅读最后评级说明和重要声明 2 / 28 %% %% %% %% resea ...

Investment Rating - The report maintains a "Positive" investment rating for the industry [10]. Core Insights - In the short term, the electricity gap in North America continues to widen, leading to a supply-demand imbalance for gas turbines, which presents an opportunity for gas generator sets to become the primary power source [3][9]. - In the medium to long term, gas generator sets are expected to become a preferred choice for small to medium-sized data centers due to their advantages in speed of delivery and operational efficiency [3][9]. - Domestic companies, such as Weichai Power and Yinlun Co., are well-positioned to benefit from this opportunity due to their production capacity and quick delivery capabilities [3][9]. Summary by Sections Background - The demand for AI computing power has surged, resulting in a projected electricity gap of approximately 73.2 GW in the U.S. from 2025 to 2030, which could increase to 201 GW if data center growth exceeds expectations [6][27]. Demand - Gas generator sets are expected to experience explosive growth in the short term due to the electricity shortage, with a projected demand of about 9 GW for gas generator sets in North America by 2026 [7][56]. - The medium to long-term outlook indicates that gas generator sets will be favored for their modularity and lower redundancy costs, particularly for data centers with capacities around 100 MW [8][58]. Supply - There is a significant supply shortage of gas generator sets from overseas manufacturers, while domestic companies like Weichai Power can deliver quickly due to their ample production capacity [8][73]. Investment Recommendations - The report suggests a strong growth cycle for gas generator sets in North America, driven by the ongoing electricity shortage and the limited supply of gas turbines [9][3].

丨证券研究报告丨 行业研究丨行业周报丨金属、非金属与采矿 [Table_Title] 假期金属价格走强，看好节后配置机遇 报告要点 [Table_Summary] 铜铝节后易涨难跌，重视板块机会。商品端，铜铝节后易涨难跌，中长期经济底部与逆全球化 促进供需结构优化，弹性可期：1）短期，美国对降息及铜关税态度，依然是短期工业金属价格 走势的主导因素，在二者并未发生根本性转变之前，维持铜铝趋势看涨判断，节后国内金三银 四旺季、中美会谈、联储主席换届等均构成催化；2）中期，美联储降息引领全球趋势宽松促进 铜铝周期上行；3）长期，逆全球化加剧各国对资源争夺，铜铝中枢趋势上行。 分析师及联系人 [Table_Author] 王鹤涛 肖勇 叶如祯 王筱茜 肖百桓 SAC：S0490512070002 SAC：S0490516080003 SAC：S0490517070008 SAC：S0490519080004 SAC：S0490522080001 SFC：BQT626 SFC：BUT918 SFC：BWM115 请阅读最后评级说明和重要声明 %% %% %% %% research.95579.com 1 丨证券研究报 ...

丨证券研究报告丨 [Table_scodeMsg2] 联想集团（00992.HK） cjzqdt11111 [Table_scodeMsg1] 港股研究丨公司点评丨联想集团（00992.HK） [Table_Title] 龙头穿越周期，多项业务创历史新高 报告要点 [Table_Summary] 联想 FY2026Q3（对应日历年 2025Q4，下同）实现营收 222.04 亿美元，同比增长 18%；毛 利率 15.1%，同比下降 0.6pct；归母净利润 5.46 亿美元，同比下降 21%，主因一次性重组费 用、认股权证的非现金公允价值收益等非现金项目的影响；经调整净利润 5.89 亿美元，同比增 长 36%。 分析师及联系人 [Table_Author] 杨洋 SAC：S0490517070012 SFC：BUW100 请阅读最后评级说明和重要声明 %% %% %% %% research.95579.com 1 [Table_Title2] 龙头穿越周期，多项业务创历史新高 [Table_Summary2] 事件描述 联想 FY2026Q3（对应日历年 2025Q4，下同）实现营收 222.04 亿美元 ...

Investment Rating - The report maintains a "Positive" investment rating for the industry [9] Core Insights - As of February 22, the cumulative year-on-year growth rate of national express delivery volume for the first five weeks of the year is 1.9%, a significant slowdown compared to 29.3% in the same period last year. This slowdown is attributed to increased compliance costs due to precise tax audits and the positive price growth resulting from regulatory measures against excessive competition. The industry is expected to maintain single-digit growth rates through 2026, with leading companies likely to gain market share [2][4][5]. Summary by Sections Industry Overview - The express delivery volume growth has significantly slowed, with the current growth rate at 1.9% compared to 29.3% last year. This is primarily due to increased compliance costs for merchants and a positive price growth trend since September 2025 [4][5]. Market Dynamics - The leading express companies are expected to see their market share increase as the competitive landscape shifts. In January, the growth rates for major companies were as follows: YTO Express at 29.8%, Shentong Express at 25.6%, and Yunda Express at 10.8% [4][5]. Recommendations - The report recommends focusing on leading express companies such as Zhongtong and Yuantong, which are currently valued at historical lows. Attention is also drawn to SF Express, which has been optimizing its product structure and is expected to see a profitability turnaround [5]. Logistics Data - Air freight prices have remained stable despite the off-peak season, with strong demand for high-tech products contributing to this trend. The average utilization rates for Eastern Airlines and Southern Airlines logistics are reported at 10.7 hours and 14.0 hours, respectively [7][28].

1. Report Industry Investment Rating No relevant content provided. 2. Core Viewpoints of the Report - The high - frequency data during the 2026 Spring Festival shows that the "quantity" of travel and tourism consumption continued to recover, but the price recovery lagged; the logistics was differentiated, with strong foreign trade resilience and weak production and consumption logistics; the volume of hotels and scenic spots increased while the price decreased, and the box office was weak; the real - estate market continued to be under pressure, with weak transactions in both new and second - hand housing. With the price increase in the second half of last year and the carry - over effect, it is highly likely that the subsequent fundamentals will shift from "trading price for volume" to "trading volume for price". Currently in a low - interest - rate environment in China, minor fundamental changes have limited impact on the bond market, and the view of a volatile bond market is maintained. The short - end of the bond market depends on the central bank, and the carry - trade strategy may continue. The long - end, especially the 30 - year treasury bond, needs to focus on fiscal efforts and the bank's carrying capacity. In the medium - term, the inflation theme should be monitored [1][4][7][77]. 3. Summary by Relevant Catalogs 3.1. Travel: Long holidays release travel demand, and self - driving travel is popular - The demand for family visits and tourism during the Spring Festival was continuously released, and the overall passenger volume remained high. As of the sixth day of the first lunar month, during the first 21 days of the Spring Festival travel rush, the overall passenger volume increased by 6.0% year - on - year. Among different transportation modes, the waterway had the highest growth rate, with railway, civil aviation, highway, and waterway passenger volumes increasing by 5.3%, 5.5%, 6.0%, and 23.1% respectively [10]. - The cross - regional population flow during the Spring Festival travel rush in 2026 reached a new high in recent years, with a significant increase in travel willingness. The peak occurred on the sixth day of the first lunar month, with a 12.3% increase compared to 2025, a 20.6% increase compared to 2024, and a 46.9% increase compared to 2019 [10]. - There was an obvious characteristic of off - peak travel before the festival. The growth compared to 2025 was mainly concentrated in the post - festival peak, while the improvement compared to 2024 started from the 24th day of the twelfth lunar month. The growth compared to 2019 was throughout the whole period, indicating that the long holiday catalyzed the release of residents' travel demand [11]. - The travel choices during the Spring Festival travel rush in 2026 were dominated by self - driving, reflecting residents' preference for short - distance travel. The proportion of non - commercial highway (mainly private cars) flow reached 81.6%, a 11.9 - percentage - point increase compared to 2019 [18]. - The domestic flight volume, passenger volume, and occupancy rate remained prosperous, but the price recovery was weak, and the pattern of "trading price for volume" was difficult to reverse in the short term. The domestic flight volume increased by 4.0% year - on - year, the passenger volume increased by 6.5%, the occupancy rate increased by 1.2%, and the domestic oil - included ticket price decreased by 1.5% [22]. 3.2. Logistics: Foreign trade shows resilience, while production and consumption logistics weaken in advance - The national logistics near the Spring Festival in 2026 showed a pattern of "strong foreign - trade resilience, high - then - low production logistics, and early - weakening consumption logistics". The container throughput maintained a year - on - year positive growth of 9.3% - 12.2% in the four weeks before the festival, but the growth rate of the monitored port cargo throughput fluctuated and declined [34]. - The production logistics was high in the early stage and low in the later stage. The national highway truck traffic volume increased by 4.3% and 2.6% year - on - year in the four and three weeks before the festival respectively, but the growth rate slowed down and turned negative in the last two weeks before the festival, indicating a rapid contraction of production logistics near the holiday [34]. - The consumption logistics contracted in advance. The postal express collection volume declined from 9.2% four weeks before the festival to 0.5% one week before the festival, and the delivery volume declined from 7.9% to 1.4%, suggesting that the peak of New Year goods delivery was earlier than last year [34]. - The railway transportation was stable, and civil aviation continued to grow. The national railway freight volume fluctuated slightly around zero, and the civil aviation flight volume maintained a positive growth of 4.8% - 6.0% [34]. 3.3. Tourism Consumption: Hotels and Scenic Spots See Volume Increase but Price Decrease, and the Box Office is Weak - The hotel occupancy rate increased, but the price was under pressure. The occupancy rate of the overall sample of Chinese mainland hotels increased from 54.7% five weeks before the festival to 64.0% one week before the festival, a year - on - year increase of 11.7%. However, the revenue per available room (RevPAR) and the average daily rate (ADR) decreased compared to last year [40]. - The scenic spots' business improved. The number of tourists in many provincial - level key - monitored scenic spots increased significantly, and the revenue of some popular scenic spots also increased substantially. For example, the revenue of Zhangjiajie Huanglongdong increased by 79% [42][45]. - Hainan's tourism consumption recovered strongly, with both volume and price increasing. The number of passengers at Haikou Meilan Airport increased day by day, and the off - island duty - free shopping also rebounded significantly. From February 15 - 19, the shopping amount, number of people, and per - capita consumption were 13.8 billion yuan, 17.7 million person - times, and 7,797 yuan respectively, with year - on - year increases of 19%, 24.6%, and - 4.5% [45]. - The Spring Festival movie market had a weak performance in both volume and price. The 7 - day cumulative box office from New Year's Eve to the sixth day of the first lunar month was 5.09 billion yuan, with a recovery rate of only 86% compared to 2019, and the average ticket price decreased by 5% year - on - year [47]. 3.4. Real Estate: Both New and Second - hand Housing Transactions are Weak, and the Volume and Price in First - tier Cities are Declining - The new - housing market had a significant decline in transaction volume. The transaction area of commercial housing in 30 large and medium - sized cities in the two months before the Spring Festival in 2026 was significantly lower than the same period in the past five years. In the first week before the festival, it was only 1.102 million square meters, a year - on - year decrease of 36.6%, and during the Spring Festival week, it was 83,000 square meters, a year - on - year decrease of 20.4% [61]. - The second - hand housing market was weak in both volume and price. The 7 - day moving average (7DMA) of the second - hand housing transaction area in 12 cities was only 247,200 square meters in the first week before the Spring Festival, a year - on - year decrease of 15.3%. The national second - hand housing listing price index continued to decline, with a 7.0% year - on - year decrease in the first week before the festival [61]. - The land market was also sluggish. The premium rate of land transactions in 100 large and medium - sized cities was 2.42% in the first week before the festival, significantly lower than 9.86% in the same period last year [62]. 3.5. How will the Bond Market Price the Spring Festival Holiday Data? - The real - estate market is still in a downward pressure channel, with weak sales volume and price, especially in some first - tier cities where housing prices may decline at an accelerated pace. The consumer data shows a rapid recovery in volume but pressure on prices, continuing the "trading price for volume" trend. With the price increase in the second half of last year and the carry - over effect, it is likely that the fundamentals will shift from "trading price for volume" to "trading volume for price" [77]. - In the current low - interest - rate environment in China, minor fundamental changes have limited impact on the bond market. The view of a volatile bond market is maintained. The short - end of the bond market depends on the central bank, and the carry - trade strategy may continue. The long - end, especially the 30 - year treasury bond, needs to focus on fiscal efforts and the bank's carrying capacity. In the medium - term, the inflation theme should be monitored [77].

%% %% 行业研究丨深度报告丨电气设备 [Table_Title] 美国加码 AIDC 自建电源，变压器&储能景气 有望加速——美国缺电研究系列三 %% %% research.95579.com 1 丨证券研究报告丨 报告要点 [Table_Summary] 此前，我们在《解能源桎梏，扬时代风帆——美国缺电深度研究》中指出，AI 电力需求高增下， 美国电力缺口不断放大，公用电网短期难以解决，导致电价不断上涨。2026 年以来，在立法层 面，FERC、州政府及区域输电组织加速推进大型负载并网政策落地，数据中心自建电源已是 大势所趋。本报告重点阐述北美数据中心供电及配储架构，量化测算自建电源对变压器及储能 需求的拉动。 分析师及联系人 [Table_Author] 邬博华 曹海花 司鸿历 SAC：S0490514040001 SAC：S0490522030001 SAC：S0490520080002 SFC：BQK482 SFC：BVD284 袁澎 SAC：S0490524010001 请阅读最后评级说明和重要声明 2 / 23 %% %% %% %% research.95579.com 2 [Table_ ...