行 业 研 医药生物 2026 年 02 月 01 日 究 靶向 PAM 通路潜在百亿美元市场：和黄医药及 Celcuity 投资要点： 行 业 定 期 报 告 行情回顾：本周（2026 年 1 月 26 日- 2026 年 1 月 30 日）中信医药指数下 跌 3.3%，跑输沪深 300 指数 3.4pct，在中信一级行业分类中排名第 22 位；2026 年初至今中信医药生物板块指数上涨 3.0%，跑赢沪深 300 指数 1.3 pct，在中 信行业分类中排名第 18 位。本周涨幅前五的个股为：凯普生物（+ 26.5%）、 华兰疫苗（+ 12.8%）、德展健康（+ 8.8%）、万泽股份（+ 7.9%）、华康医疗 （+ 6.9%）。 靶向 PAM 通路市场空间大，关注 Celcuity、和黄医药：PAM 通路突 变发生在 38%肿瘤患者中，其中覆盖乳腺癌和前列腺癌两大癌种。靶向 PAM 潜在收入与 CDK4/6 和 AR 疗法相当（80-100 亿美金），由于过往开 发药物的疗效有限，PAM 抑制剂的药物收入在其他靶向治疗类别中占比很 小。Celcuity 开发的 Gedatolisib 是唯一在 PIK3C ...

行 业 研 究 华福证券 Clawdbot ：Open Claw 新起点 投资要点： 一、Clawdbot 更名 OpenClaw 行 业 动 态 跟 踪 据 AI 寒武纪，开源个人 AI 助手项目 Clawdbot 正式宣布其最终 名称为"OpenClaw"。根据腾讯科技，Clawdbot 运行在本地 Mac 或 服务器，通过聊天软件作为交互入口，可以直接操控本地文件、终端、 甚至浏览器。 二、Clawdbot 对"模型"的影响：模型的"Agent Coding 能力" 1、海外：根据 Github，它推荐使用 Anthropic Pro/Max (100/200) 搭 配 Opus 4.5，因为它在长上下文处理方面表现更强，并且具有更好的 抗提示词注入能力。 2、国内：根据 Minimax，项目上线初期，MiniMax 即接入其技术 生态，为开发者提供模型能力层面的支持。 三、Clawdbot 对"操作系统"的影响：Mac 和 Linux 成主力 1、Mac 系统：根据澎湃新闻，Clawdbot 让已经卖了一年多的 M4 Mac mini 海外社区迎来了一波明显的订单高峰。这主要是由于 Mac 系 统深度 ...

行 业 研 华福证券 国防军工 2026 年 02 月 01 日 1 月 28 日，中国商火强调，坚决打赢主力箭首飞及回收攻坚战，全力 突破可重复使用技术。 1 月 29 日，航天科技集团召开商业航天器及应用产业链共链行动大会， 会上于国斌表示，国家航天局深入学习贯彻习近平总书记关于商业航天高 质量发展的重要指示批示精神，将商业航天纳入国家航天发展总体布局； 华福证券 证 1 月 29 日，中国航天科技集团表示，"十五五"时期将开展"天工开 物"重大专项论证，建设太空资源开发综合实验和地面支持系统，重点突 破小天体资源勘查、智能自主开采、低成本转移运输、在轨处理等关键技 术。 券 研 究 报 1 月 29 日，航天科技集团表示：未来十年，是我国加快建设航天强国 的"关键十年"，"十五五"更是关键时期，中国商业航天明确"五个一 流"新目标。 国防军工 究 行 业 定 期 报 告 军工本周观点：火箭融资元年——供应链扩产时 刻 投资要点： 本周核心观点： 本周（1.26-1.30）申万军工指数（801740）下降 7.69%，同期沪深 300 指数上升 0.08%，相对超额-7.77pct。 我们认为，投资端应持 ...

Investment Rating - The report maintains a strong rating for the pharmaceutical sector, indicating it is expected to outperform the market [6]. Core Insights - The targeted PAM pathway represents a potential market of approximately $10 billion, with significant implications for breast and prostate cancer treatments [4][16]. - Celcuity's Gedatolisib is highlighted as a promising PAM inhibitor, showing comparable efficacy to existing therapies and is under FDA priority review with a PDUFA date set for July 17, 2026 [4][37]. - The report emphasizes the importance of innovation and international expansion in the pharmaceutical industry, suggesting that companies focusing on these areas will likely thrive [4]. Summary by Sections Targeted PAM Pathway - The PAM pathway is identified as one of the most underdeveloped targets in solid tumors, with mutations occurring in 38% of cancer patients [4][16]. - Gedatolisib is noted for its effectiveness across various PI3K subtypes and its potential to establish new treatment standards in HR+/HER2- advanced breast cancer [25][37]. - HMPL-A251, developed by Hutchison China MediTech, is a HER2-targeted PAM inhibitor that has shown strong anti-tumor activity in both HER2-positive and low-expressing tumors [41][50]. Market Review and Trends - The report reviews the performance of the pharmaceutical sector from January 26 to January 30, 2026, noting a decline of 3.3% in the CITIC Pharmaceutical Index, which underperformed the CSI 300 Index by 3.4 percentage points [3][60]. - The report highlights the best-performing stocks during this period, including Cap Bio (+26.5%) and Hualan Biological (+12.8%) [3][74]. - The overall valuation of the pharmaceutical sector as of January 30, 2026, is reported at 29.09, reflecting a slight decrease of 0.87% [69].

半导体 2026 年 02 月 01 日 行 业 定 期 报 告 我们在此前周报第 1 期 20260110 中明确提出"看好商业航天产业 趋势，预计未来我国可回收火箭的成功回收将降低单次发射成本，有 望成为行业加速发展的拐点"，我们观察到国内和海外产业进展迅速， 可回收火箭核心公司蓝箭航天的 IPO 进程在 25 年 12 月 31 日被上交所 受理后，不到一个月的时间，在 26 年 1 月 22 日就达到"已问询"， 上市进程大超预期，凸显国内政策对产业发展的支持，我们坚定看好 商业航天产业链在 2026 年的加速发展机遇。 SpaceX 申请部署百万颗卫星，太空"军备竞赛"持续：1 月 31 日据 C114 报道，SpaceX 向美国联邦通信委员会（FCC）申请发射并 运营一个至多 100 万颗卫星组成的星座，相关文件显示其正在规划"轨 道数据中心系统（Orbital Data Center system）"，这些卫星拟运行在 500 公里至 2000 公里的不同轨道壳层中，相关文件显示其目的在于满 足日益增长的 AI/机器学习/边缘计算等需求。 持续看好星间激光通信和手机直连卫星环节：我们认为 6G= ...

有色金属 2026 年 02 月 01 日 行 业 有色金属 研 究 20260201 周报：市场现货紧张，镨钕价格大幅上 涨 投资要点： 行 业 定 期 报 告 贵金属：美避险需求叠加美元走低，黄金价格继续强势上涨。周内美 国总统特朗普重塑国际关系引发的疯狂上涨，以及投资者纷纷逃离主权债 券和货币市场，正推动市场对贵金属的避险需求。全球地缘政治风险的急 剧上升，是推动金价创下新高的核心驱动力之一。中长期而言，全球关税 政策和地缘政治的不确定性背景下，避险和滞涨交易仍是黄金交易的核心， 长期配置价值不改。个股：黄金关注招金灵宝万国紫金黄金，A股关注紫金、 中金、赤峰及西金等；H股关注潼关、山金、招矿及集海等。银铂钯均为黄 金的贝塔，个股关注盛达、湖银、豫光、贵研及浩通等。 工业金属：风险集中资金冲动，周四沪铜盘面大涨。铜，本周四沪铜 合约走势风云突变，上海期货交易所金属板块呈现全线大涨格局，多品种 创显著涨幅，其中沪铜2603强势领涨有色金属板块，早盘收盘价暴涨 +6.35%。整体来看，宏观风险事件集中导致的资金冲动是主因。铝，国内 方面：周初央行再次重申2026年将继续实施好适度宽松的货币政策，沪铝 价格回 ...

Investment Rating - The report does not explicitly state an overall investment rating for the industry, but it highlights several investment opportunities across different sectors within the chemical industry. Core Insights - The report emphasizes the approval of the Longhua New Material's polyether project, which is expected to enhance the company's market position and profitability in the domestic polyether sector [3]. - China National Petroleum Corporation (CNPC) has achieved large-scale production of polyolefin elastomers using gas-phase technology, reducing reliance on imports for strategic emerging industries like photovoltaics [3]. - The report identifies several investment themes, including the competitiveness of domestic tire manufacturers, the potential recovery in consumer electronics, and the resilience of certain cyclical industries [4]. Summary by Sections Market Performance - The Shanghai Composite Index fell by 0.44%, while the CSI 300 rose by 0.08%. The CITIC Basic Chemical Index decreased by 2.4% [13]. - The top-performing sub-industries included dye chemicals (11.76%), compound fertilizers (4%), and phosphate fertilizers (2.63%), while modified plastics (-7.72%) and potassium fertilizers (-7.61%) were among the worst performers [16]. Key Industry Developments - Longhua New Material's project for producing 200,000 tons of environmentally friendly polyether products has been approved, with a total investment of 600 million yuan, expected to be completed by 2028 [3]. - CNPC's breakthrough in gas-phase production of polyolefin elastomers is set to alleviate import dependence for high-end materials crucial for photovoltaic applications [3]. Investment Themes - **Tire Industry**: Domestic tire companies are becoming increasingly competitive, with recommended stocks including Sailun Tire, Senqilin, and Linglong Tire [4]. - **Consumer Electronics**: A gradual recovery is anticipated, with upstream material companies expected to benefit. Key companies to watch include Dongcai Technology and Stik [4]. - **Cyclical Industries**: Focus on industries with strong resilience and inventory destocking, particularly in phosphate and fluorine chemicals, is advised [4]. - **Vitamin Supply**: Supply disruptions in vitamins A and E due to BASF's force majeure are expected to create supply imbalances, with companies like Zhejiang Medicine and New Hecheng recommended [7]. Sub-Industry Reviews - **Polyurethane**: The report notes price fluctuations in MDI and TDI, with current prices at 17,500 yuan/ton and 14,300 yuan/ton respectively [27][32]. - **Tire Production**: The operating rate for all-steel tires is at 62.41%, while semi-steel tires are at 75.35%, indicating a strong demand in the market [49]. - **Fertilizers**: Urea prices have increased to 1,776.7 yuan/ton, with a slight decrease in production rates noted [62]. Price Trends - The average price for vitamin A is reported at 61.5 yuan/kg, while vitamin E has seen a slight increase to 55.5 yuan/kg [77]. - The price of萤石 has risen to 3,375 yuan/ton, reflecting a 1.5% increase [81]. This summary encapsulates the key points from the industry report, highlighting investment opportunities and market dynamics without including risk warnings or disclaimers.

华福证券 2026 年 02 月 01 日 固 定 收 益 央行新工具意义何在 地方债发行放量期限压缩 —— 流动性与机构行为周度跟踪 260201 投资要点： 固 定 收 货币市场：本周 OMO 合计净投放 5805 亿元，本周一有 2000 亿元 MLF 到期，周三财政部开展 1500 亿元 1M 国库现金定存操作，中标利率 连续 3 月维持在 1.73%。本周初 OMO 净投放规模有限，但 MLF 到期叠 加缴准以及政府债大量缴款，使得资金边际收紧，但此后外生扰动减弱， 临近月末央行投放规模也逐步增大，DR001 回落至 1.33%附近。 益 定 期 报 告 质押式回购成交量周一后持续回落；质押式回购整体规模周四前震荡 回升，周五明显回落。大型银行净融出在周一下行后维持震荡，中小型银 行净融出周四前持续上行，周五回落但仍高于上周；银行整体净融出维持 震荡，中枢较上周略有回落。非银刚性融出持续上升，其中货基、其他产 品、理财融出延续上升。非银刚性融入震荡上行，其中其他产品升幅较大。 资金缺口指数在周一上行后持续回落，但周五再度走高，季调后指数升至- 4098，略高于上周五的-4961，而季调前指数周五为- ...

Investment Rating - The report maintains an "Outperform" rating for the light industry manufacturing sector [3] Core Insights - The sentiment in the real estate chain continues to improve, leading to a significant recovery in the valuations of leading home furnishing companies. Recommendations include Gujia Home, Oppein Home, and others, while also monitoring undervalued companies like Minhua Holdings and Zhibang Home [2] - Suzano, a Brazilian company, plans to increase the price of hardwood pulp by $10 per ton starting in February, which is expected to support paper prices. Continued recommendations include Sun Paper and attention to Jiulong Paper and Bohui Paper [2] Summary by Sections Home Furnishing - The home furnishing sector is experiencing a valuation recovery due to improved policy expectations and a rebound in second-hand housing transactions. In 2025, Shanghai's second-hand home transactions reached 254,000 units, the highest in four years, indicating a marginal improvement in supply-demand dynamics [6][12] - The sector's valuation and institutional holdings are at historical lows, suggesting a potential for short-term recovery in valuations [6] Paper Industry - As of January 30, 2026, the prices for various paper types remained stable, with double glue paper at 4725 CNY/ton, copper plate paper at 4660 CNY/ton, and white card paper at 4269 CNY/ton. However, box board paper saw a slight decrease to 3517.2 CNY/ton, while corrugated paper increased to 2676.25 CNY/ton [6][53] - The paper industry is expected to benefit from the price increase in hardwood pulp, with a projected rise of $10 per ton in Asian markets [6] Packaging - Xianggang Technology forecasts a net profit of 100 million to 138 million CNY for the year, representing a year-on-year increase of 52.14% to 109.95% [6] - The company has received global certification for its PHA film products, enhancing its market position [6] Export Chain - The export chain is facing pressure due to the depreciation of the dollar and high performance baselines from the previous year. However, there is potential for recovery as U.S. interest rates decrease and real estate sales improve [6] Light Industry Consumption - Zhongshun Jierou expects a net profit of 300 million to 330 million CNY for 2025, a year-on-year increase of 289% to 328%, driven by lower raw material costs and improved operational efficiency [6] - Recommendations include focusing on dental care leader Dengkang Oral and medical products driven by high growth in cotton soft towels and sanitary napkins [6] New Tobacco Products - Altria reported a net revenue of $23.279 billion for 2025, a decrease of 3.1%, primarily due to significant non-cash impairment charges in its e-cigarette business [6] Textile and Apparel - Huafu Fashion anticipates a net profit of 55 million to 75 million CNY for 2025, with a year-on-year growth of 126.47% to 136.10% [6]

1. Report Industry Investment Rating No information provided in the content. 2. Core Viewpoints of the Report - Interest rates are fluctuating narrowly, credit bond yields have slightly declined, and most credit spreads are still narrowing. [3][9] - Most urban investment bond spreads have decreased by 1 - 2BP. [14] - Real - estate bond spreads are still widening, while most other industrial bond spreads are converging. [25] - This week, Tier 2 and perpetual bonds (Two - and - Perpetual bonds, "Two - and - Perpetual" bonds refer to bank Tier 2 capital bonds and perpetual bonds) have shown weak performance. Except for the 5Y variety, most yields have increased. [4][33] - The excess spread of 3Y industrial perpetual bonds has narrowed, while the excess spread of urban investment bonds has shown differentiation. [4][36] 3. Summary According to Relevant Catalogs 3.1 Interest rates are fluctuating narrowly, credit bond yields have slightly declined, and most credit spreads are still narrowing - Interest - rate bond yields fluctuated narrowly. The yields of 1Y and 10Y China Development Bank bonds increased by 1BP, the yield of 3Y decreased by 1BP, and the yields of 5Y and 7Y remained flat. [3][9] - Credit bond yields generally declined slightly. The yields of 1Y AA + and above - grade credit bonds increased by 1BP, while the other grades remained flat; the yield of 3Y AAA remained flat, and the other grades decreased by 2 - 4BP; the yields of 5Y AA + and above - grade remained flat, and the other grades increased by 1BP; the yields of 7Y all grades decreased by 1 - 3BP; the yields of 10Y all grades increased by 1BP. [3][9] - Most credit spreads slightly converged. The credit spreads of 1Y AA + and above - grade remained flat, and the other grades narrowed by 1BP; the spread of 3Y AAA increased by 1BP, the spread of AA - decreased by 1BP, and the other grades compressed by 3BP; the spreads of 5Y AA + and above - grade remained flat, and the other grades widened by 1BP; the spreads of 7Y all grades narrowed by 1 - 3BP; the spreads of 10Y all grades narrowed by 1BP. [3][9] 3.2 Most urban investment bond spreads have decreased by 1 - 2BP - In terms of external ratings, the credit spreads of external - rated AAA platforms generally decreased by 1BP compared with last week, and the credit spreads of AA + and AA platforms generally decreased by 2BP. [14] - By administrative level, the credit spreads of provincial - level platforms generally decreased by 1BP compared with last week, and the credit spreads of prefecture - level and district - county - level platforms generally decreased by 2BP. [19] 3.3 Real - estate bond spreads are still widening, while most other industrial bond spreads are converging - Most industrial bond spreads converged. The spread of Vanke continued to compress significantly, but the spreads of central and state - owned enterprise real - estate bonds and other private - enterprise real - estate bonds still widened overall. [25] - The spreads of central and state - owned enterprise real - estate bonds widened by 1 - 3BP, the spread of mixed - ownership real - estate bonds converged by 188BP, and the spread of private - enterprise real - estate bonds increased by 15BP. [25] - The spread of Longfor decreased by 2BP, that of CIFI increased by 49BP, that of Vanke decreased by 1802BP, that of Midea Real Estate decreased by 1BP, that of Huafa increased by 13BP, and that of Poly increased by 3BP. [25] - The spread of AA - grade coal bonds increased by 1BP, and the other grades decreased by 1BP; the spread of AAA - grade steel bonds remained flat, and that of AA + decreased by 2BP; the spread of AAA - grade chemical bonds remained flat, and that of AA + decreased by 1BP. [25] 3.4 This week, Tier 2 and perpetual bonds have shown weak performance. Except for the 5Y variety, most yields have increased - The yields of 1Y all - grade Tier 2 capital bonds remained flat, and the spreads decreased by 0 - 1BP; the yields of all - grade perpetual bonds increased by 1 - 2BP, and the spreads increased by 0 - 1BP. [33] - The yields of 3Y all - grade Tier 2 capital bonds increased by 2 - 3BP, and the spreads widened by 3 - 4BP; the yields of all - grade perpetual bonds remained flat, and the spreads widened by 1BP. [33] - The yields of 5Y all - grade Tier 2 capital bonds decreased by 0 - 2BP, the yields of perpetual bonds remained flat, and the spreads changed by the same margin. [33] - The yields of 10Y all - grade Tier 2 capital bonds increased by 2 - 5BP, and the spreads widened by 1 - 3BP; the yields of perpetual bonds increased by 5BP, and the spreads increased by 3BP. [33] 3.5 The excess spread of 3Y industrial perpetual bonds has narrowed, while the excess spread of urban investment bonds has shown differentiation - The excess spread of industrial AAA - grade 3Y perpetual bonds converged by 0.76BP compared with last week to 13.91BP, at the 36.17% percentile since 2015. The excess spread of industrial 5Y perpetual bonds remained the same as last week at 13.21BP, at the 33.60% percentile since 2015. [36] - The excess spread of urban - investment AAA - grade 3Y perpetual bonds increased by 0.83BP to 4.86BP, at the 5.43% percentile. The excess spread of urban - investment 5Y perpetual bonds decreased by 3.72BP to 9.62BP, at the 11.15% percentile. [36] 3.6 Credit Spread Database Compilation Instructions - The overall market credit spreads, commercial bank Tier 2 and perpetual spreads, and urban - investment/industrial perpetual bond credit spreads are calculated based on ChinaBond Medium - and Short - Term Notes and ChinaBond Perpetual Bonds data. The historical percentiles are since the beginning of 2015. [38] - The credit spreads related to urban - investment and industrial bonds are compiled and statistically analyzed by the Huafu Securities Research Institute, and the historical percentiles are since the beginning of 2015. [38] - The credit spreads of industrial and urban - investment individual bonds = the ChinaBond valuation (exercise) of individual bonds - the yield to maturity of the same - term China Development Bank bonds (calculated by the linear interpolation method), and finally the arithmetic average method is used to calculate the credit spreads of the industry or regional urban - investment bonds. [40] - The excess spread of bank Tier 2 capital bonds/perpetual bonds = the credit spread of bank Tier 2 capital bonds/perpetual bonds - the credit spread of bank ordinary bonds of the same grade and term. The excess spread of industrial/urban - investment perpetual bonds = the credit spread of industrial/urban - investment perpetual bonds - the credit spread of medium - term notes of the same grade and term. [40] - Sample screening criteria and other information: Both industrial and urban - investment bonds select medium - term notes and public - offering corporate bond samples, and exclude guaranteed bonds and perpetual bonds. If the remaining term of an individual bond is less than 0.5 years or more than 5 years, it will be excluded from the statistical samples. Industrial and urban - investment bonds are all external entity ratings, while commercial banks use ChinaBond implicit debt ratings. [40]